Gay Drug – Gay Drug Poppers. Popper is a slang term given broadly to the chemical class called alkyl nitrites, that are inhaled for recreational drug purposes, typically for the “high” or “rush” that the drug can create. Poppers have also been historically used for sexual encounters, initially within the gay community. Popper use has a relaxation effect on involuntary smooth muscles, such as those in the throat and anus. Hence why they are referred to as a Gay Drug.